4.7 Review

Potential for improvement of docetaxel-based chemotherapy: a pharmacological review

Journal

BRITISH JOURNAL OF CANCER
Volume 93, Issue 2, Pages 173-177

Publisher

NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6602698

Keywords

docetaxel; taxotere; taxanes; pharmacology

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Since the introduction of docetaxel, research has focused on various approaches to overcome treatment limitations and improve outcome. This review discusses the pharmacological attempts at treatment optimisation, which include reducing interindividual pharmacokinetic and pharmacodynamic variability, optimising schedule, route of administration, reversing drug resistance and the development of structurally related second-generation taxanes. (c) 2005 Cancer Research UK.

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