Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 102, Issue 30, Pages 10415-10420Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0504099102
Keywords
mathematical model; receptor neuron; olfaction; signal transcluction; cilia
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Funding
- NCRR NIH HHS [9 R01 RR1466] Funding Source: Medline
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We develop a mechanistic mathematical model of the G-protein coupled signaling pathway responsible for generating current responses in frog olfactory receptor neurons. The model incorporates descriptions of ligand-receptor interaction, intracellular transduction events involving the second messenger cAMP, effector ion-channel activity, and calcium-mediated feedback steps. We parameterized the model with respect to suction pipette current recordings from single cells stimulated with multiple odor concentrations. The proposed model accurately predicts the receptor-current response of the neuron to brief and prolonged odorant exposure and is able to produce the adaptation observed under repeated or sustained stimulation.
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