Journal
CELL
Volume 122, Issue 2, Pages 247-260Publisher
CELL PRESS
DOI: 10.1016/j.cell.2005.05.013
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Funding
- NCI NIH HHS [CA-046934] Funding Source: Medline
- NIAID NIH HHS [AI-17134, AI-18785, AI-52225, AI-22295] Funding Source: Medline
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T cells bearing up T cell receptors (TCRs) recognize antigens in the form of peptides bound to class I or class II major histocompatibility proteins (MHC). TCRs on mature T cells are usually very specific for both peptide and MHC class and allele. They are picked out from a precursor population in the thymus by MHC-driven positive and negative selection. Here we show that the pool of T cells initially positively selected in the thymus contains many T cells that are very crossreactive for peptide and MHC and that subsequent negative selection establishes the MHC-restriction and peptide specificity of peripheral T cells. Our results also suggest that germline-encoded TCR variable elements have an inherent predisposition to react with features shared by all MHC proteins.
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