Journal
VIBRATIONAL SPECTROSCOPY
Volume 38, Issue 1-2, Pages 169-177Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.vibspec.2005.02.028
Keywords
microspectroscopy; tissue; HeLa cells; cell cycle; FTIR micro-spectroscopy; cell division
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Spectral differences between normal and abnormal tissue observed to date appear to be due to different averaging processes of spectral patterns that differ according to the cell's biochemistry, due to its state of maturation, differentiation, and development. Thus, disease perturbs the distribution of cells in the different stages of maturation, differentiation, and development. Previous FTIR microspectroscopic studies of normal versus neoplastic cells and tissues have demonstrated differences in the absorption intensities and band-shapes, particularly in the low frequency (1200-1000 cm(-1)) spectral region. In this study, we further investigated the spectral changes due to the drastic biochemical and morphological changes occurring as a consequence of cell proliferation. (c) 2004 Elsevier B.V. All rights reserved.
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