Journal
SOUTHERN MEDICAL JOURNAL
Volume 98, Issue 8, Pages 811-813Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.SMJ.0000163315.02563.B2
Keywords
colchicine; clarithromycin; drug-drug interactions
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Although colchicine is a commonly used medication in patients with gouty arthritis and various multisystem disorders, its safety margin in therapeutic use is not well understood. This report describes two fatal cases of agranulocytosis presumed to result from a drug interaction involving colchicine and clarithromycin.
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