Journal
NATURE CELL BIOLOGY
Volume 7, Issue 8, Pages 758-U19Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb0805-758
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Funding
- NIGMS NIH HHS [R01 GM063692, R01 GM 63692] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
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The transcription factor NF-kappa B (nuclear factor kappa enhancer binding protein) controls many processes, including immunity, inflammation and apoptosis. Ubiquitination regulates at least three steps in the NF-kappa B pathway: degradation of I kappa B (inhibitor of NF-kappa B), processing of NF-kappa B precursors, and activation of the I kappa B kinase (IKK). Recent studies have revealed several enzymes involved in the ubiquitination and deubiquitination of signalling proteins that mediate IKK activation through a degradation-independent mechanism.
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