Journal
CURRENT MEDICAL RESEARCH AND OPINION
Volume 21, Issue 8, Pages 1235-1240Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1185/030079905X56510
Keywords
burns; hyaluronic acid; silver sulfadiazine; wound healing
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Aims: This multicenter, multinational, randomized, double-blind, controlled, parallel-group study, was designed to assess the efficacy and safety of a fixed combination topical medicinal product, containing 0.2% hyaluronic acid and 1% silver suffadiazine (HA-SSD) (Connettivina* Plus cream) versus 1% silver sulfadiazine cream alone (SSD), in the treatment of second-degree burns. Methods: 111 adult patients (age 18-75 years) of both sexes, with IIa-degree (superficial) and IIb-degree (deep dermal) burns, were randomized to receive HA-SSD or SSD. Treatments (approximately 5g/100 cm(2)) were applied once a day until the wounds healed, but for no longer than 4 weeks. Burns had to have occurred within 48 hours from the start of treatment, be caused by thermal injury, and be confined to the trunk and/or upper and lower extremities. Results: Results showed that both the fixed combination HA-SSD, and SSD alone, were effective and well tolerated topical agents for the treatment of second-degree burns. All burns were healed except in one patient treated with SSD. It was also observed that the fixed combination HA-SSD caused a significantly more rapid re-epithelialization of burns, i.e. a shorter time to healing, than SSD alone. The difference recorded - 4.5 days - was statistically significant (p = 0.0073). Conclusion: The observed shorter time to healing caused by the fixed combination is clinically relevant and further demonstrates the wound healing activity of HA.
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