Journal
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
Volume 80, Issue 2, Pages 730-740Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.03313-13
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Funding
- Laboratory of Probiogenomics
- Fondazione Cariplo [2010-0678]
- FEMS Jensen Award
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Here, we describe data obtained from transcriptome profiling of human cell lines and intestinal cells of a murine model upon exposure and colonization, respectively, with Bifidobacterium bifidum PRL2010. Significant changes were detected in the transcription of genes that are known to be involved in innate immunity. Furthermore, results from enzyme-linked immunosorbent assays (ELISAs) showed that exposure to B. bifidum PRL2010 causes enhanced production of interleukin 6 (IL-6) and IL-8 cytokines, presumably through NF-kappa B activation. The obtained global transcription profiles strongly suggest that Bifidobacterium bifidum PRL2010 modulates the innate immune response of the host.
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