Journal
CLINICAL INFECTIOUS DISEASES
Volume 41, Issue -, Pages S204-S207Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/429999
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Funding
- NIAID NIH HHS [AI-34361, AI-42747] Funding Source: Medline
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Tumor necrosis factor (TNF)-alpha is required for host defenses against a number of pathogenic microbes, including Histoplasma capsulatum. In mice, TNF-alpha is necessary for the generation of a protective immune response to both primary and secondary histoplasmosis. Recent reports indicate that, in humans, treatment with inhibitors of TNF-alpha is associated with disseminated histoplasmosis. Here, I review the mechanisms by which inhibition of TNF-alpha may exacerbate infection with H. capsulatum.
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