Journal
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
Volume 79, Issue 19, Pages 6187-6190Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.01388-13
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Funding
- Ministry of Science and Innovation, Spain [AGL2009-13144-C02-01]
- CSIC, Spain [PIE200970I090]
- bacteriophage network FAGOMA
- Science, Technology and Innovation Programme, Principado de Asturias, Spain [IB08-052]
- Ministerio de Ciencia e Innovacion, MICINN [BIO2011-30503-C02-01, PIM2010EPA-00606]
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The role of virion-associated peptidoglycan hydrolases (VAPGHs) in the phage infection cycle is not clear. gp49, the VAPGH from Staphylococcus aureus phage phi 11, is not essential for phage growth but stabilizes the viral particles. phi 11 Delta 49 phages showed a reduced burst size and delayed host lysis. Complementation of gp49 with HydH5 from bacteriophage vB_SauS-phi-IPLA88 restored the wild-type phenotype.
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