Journal
INFECTION AND IMMUNITY
Volume 73, Issue 8, Pages 5212-5216Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.73.8.5212-5216.2005
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Funding
- NIAID NIH HHS [AI2879] Funding Source: Medline
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Since the ability of peptidoglycan (PGN) to activate Toll-like receptor 2 (TLR2) was recently questioned, we reevaluated activation of TLR2 by PGN. Polymeric soluble or insoluble Staphylococcus aureus PGN, repurified by sodium dodecyl sulfate or phenol extraction, activated TLR2 at 0.1 to 1 or 10 mu g/ml, respectively, and induced tumor necrosis factor alpha production. The TLR2 activation by PGN, but not by lipoteichoic acid, was abolished by muramidase digestion. We conclude that polymeric S. aureus PGN is a TLR2 activator.
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