Journal
TRENDS IN GENETICS
Volume 21, Issue 8, Pages 444-449Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2005.05.012
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DNA is replicated according to a precise and reproducible temporal pattern. The S-phase programme has previously been analyzed in metazoan and yeast cells using different methods: cytological chromosome banding in human cells and DNA isotopic-labeling techniques in yeast. Microarray-based approaches for the analysis of the replication programme and chromatin structure are bringing us closer to a molecular understanding of the factors that determine replication time. In this article, I assess the impact of recent investigations and compare our knowledge of DNA replication-timing controls in yeast with those of metazoans.
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