Journal
FASEB JOURNAL
Volume 19, Issue 10, Pages 1671-+Publisher
WILEY
DOI: 10.1096/fj.04-2981fje
Keywords
apoptosis; kinase; neurogenesis
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Caspase proteases have become the focal point for the development and application of antiapoptotic therapies in a variety of central nervous system diseases. However, this approach is based on the premise that caspase function is limited to invoking cell death signals. Here, we show that caspase-3 activity is elevated in nonapoptotic differentiating neuronal cell populations. Moreover, peptide inhibition of protease activity effectively inhibits the differentiation process in a cultured neurosphere model. These results implicate caspase-3 activation as a conserved feature of neuronal differentiation and suggest that targeted inhibition of this protease in neural cell populations may have unintended consequences.
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