Journal
BIOESSAYS
Volume 27, Issue 8, Pages 765-769Publisher
WILEY
DOI: 10.1002/bies.20275
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Signal transduction pathways are largely conserved throughout the animal kingdom. The repertoire of pathways is limited and each pathway is used in different intercellular signaling events during the development of a given animal. For example, Writ signaling is recruited, sometimes redundantly with other molecular pathways, in four cell specification events during Caenorhabditis elegans vulva development, including the activation of vulval differentiation. Strikingly,a recent study finds that Writs act to repress vulval differentiation in the nematode Pristionchus pacificus,((1)) demonstrating evolutionary flexibility in the use of intercellular signaling pathways.
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