Journal
BIOMATERIALS
Volume 26, Issue 23, Pages 4892-4897Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2004.11.052
Keywords
microarray; biomaterials; PLGA
Funding
- NHLBI NIH HHS [HL60435] Funding Source: Medline
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The identification of biomaterials that induce optimal gene expression patterns and allow for appropriate levels of cellular attachment is of central importance in tissue engineering and cell therapy. Herein, we describe the creation of cell-compatible, biomaterial microarrays, that allow rapid, microscale testing of biomaterial interactions with cells. As proof of principle, we simultaneously characterized over 3456 human mesenchymal stem cell (hMSC)-biomaterial composite interactions, and describe preliminary studies on the utility of these arrays with a neural stem cell line (NSC), and primary articular chondrocytes. (C) 2004 Elsevier Ltd. All rights reserved.
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