CRITICAL EVALUATION OF STABILITY CONSTANTS OF METAL COMPLEXES OF COMPLEXONES FOR BIOMEDICAL AND ENVIRONMENTAL APPLICATIONS (IUPAC Technical Report)

Available experimental data on stability constants of proton (hydron) and metal complexes for seven complexones of particular biomedical and environmental interest: iminodiacetic acid (2,2'-azanediyldiacetic acid, IDA); (methylimino)diacetic acid (2,2'-(methylazanediyl)diacetic acid, MIDA); 2,2',2 '',2'''-{[carboxymethyl)azanediyl]bis[(ethane-1,2-diyl)nitrilo]}tetraacetic acid (DTPA); 3,6,9,12-tetrakis(carboxymethyl)-3,6,9,12-tetraazatetradecanedioic acid (TTHA); 2,2',2 ''-(1,4,7-triazanonane-1,4,7-triyl)triacetic acid (NOTA); 2,2',2 '',2'''-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid (DOTA); 2,2',2 '',2'''-(1,4,8,11-tetraazacyclotetradecane-1,4,8,11-tetrayl)tetraacetic acid (TETA), published in 1945-2000, have been critically evaluated. Some typical errors in stability constant measurements for particular complexones are summarized. Higher quality data are selected and presented as Recommended or Provisional.