Journal
MELANOMA RESEARCH
Volume 15, Issue 4, Pages 283-285Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00008390-200508000-00008
Keywords
chemotherapy; c-kit; immunohistochemistry; melanoma
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In order to determine whether imatinib mesylate (Gleevec), a tyrosine kinase inhibitor that binds the CD-117 (c-kit) receptor, may be of value in the treatment of malignant melanoma, an immunohistochemical analysis of 40 cases of primary and metastatic melanoma was undertaken. Thirty-five of the 40 cases showed 1 + or stronger labelling for CD-117 (up to a maximum of 4 +). Three patients with neoplasms showing 4 + staining were selected for imatinib therapy. None responded. c-kit (CD-117) expression in melanoma appears to be common; however, the value of imatinib therapy remains to be proven.
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