Journal
TRENDS IN NEUROSCIENCES
Volume 28, Issue 8, Pages 397-400Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2005.05.008
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Neuronal induction by retinoic acid (RA) is commonly used in embryonic stem (ES) cell differentiation. Two recent papers show that this paradigm induces a population of neurogenic precursors with properties of radial glia. Upon differentiation, RA-treated cells give rise to a defined and developmentally restricted neuronal lineage. This role of RA in cell fate specification provides new perspectives for studying the radial glia-neuron transition and for generating homogenous populations of neurons from ES cells.
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