Journal
EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION
Volume 12, Issue 4, Pages 401-406Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1097/01.hjr.0000173106.68485.b7
Keywords
exercise training; chronic heart failure; skeletal muscle; growth hormone; insulin-like growth factor-I; tumor necrosis factor alpha
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Background Chronic heart failure (CHF) is associated with progressive muscle atrophy and reduced local expression of insulin-like growth factor I (IGF-I). Design The present study was designed to test the hypothesis that the local deficiency of IGF-I in the skeletal muscle of patients with CHF would respond to a 6-months aerobic training intervention. Therefore, 18 patients [mean age 52.4 (SD 4.8) years, left ventricular ejection function (LVEF) 27 (SD 6)%] were prospectively randomized to either 6 months of training or sedentary lifestyle. Methods Serum levels of growth hormone (GH) were measured by immunofluorometric assay, IGF-I by competitive solid phase immunoassay. IGF-I expression was assessed in vastus lateralis biopsies by real-time PCR. Results Exercise training led to a significant increase in peak oxygen uptake by 26% [from 20.3 (SD 3.3) ml/kg per min to 25.5 (SD 5.7)ml/kg per min, P = 0.003 versus control]. Local expression of IGF-I increased significantly after exercise training by 81% [from 6.3 (SE 0.8) to 11.4 (SE 1.4) relative units, P = 0.007 versus control] while IGF-I receptor expression was reduced by 33% [from 20.0 (SE 2-1) to 13.8 (SE 1.7) relative units, P = 0.008 versus control]. Serum growth hormone (GH) rose modestly from 0.12 (SE 0.07) to 0.65 (SE 0.37) ng/ml in the training group (P = 0.043 versus baseline), however, this change was not significant compared to the control group (P = 0.848). IGF-I serum levels remained virtually unchanged. Conclusions Exercise training improves local lGF-I expression without significant changes of systemic parameters of the GH/IGF-I axis. These findings indicate that exercise training has the therapeutic potential to attenuate peripheral skeletal muscle alterations in particular with respect to local IGF-I expression in patients with moderate CHF.
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