4.6 Article

The Bacterial Surface Layer Provides Protection against Antimicrobial Peptides

Journal

APPLIED AND ENVIRONMENTAL MICROBIOLOGY
Volume 78, Issue 15, Pages 5452-5456

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.01493-12

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Funding

  1. Canadian Institutes for Health Research
  2. Cystic Fibrosis Canada
  3. Canadian Natural Sciences and Engineering Research Council (NSERC)
  4. Fundacion la Caixa
  5. Fundacion Canada (Spain)

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This report describes a previously unrecognized role for bacterial surface layers as barriers that confer protection against antimicrobial peptides. As antimicrobial peptides exist in natural environments, S-layers may provide a bacterial survival mechanism that has been selected for through evolution.

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