Journal
BIOESSAYS
Volume 27, Issue 8, Pages 785-794Publisher
WILEY-BLACKWELL
DOI: 10.1002/bies.20268
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Funding
- NCI NIH HHS [BCS-0218338] Funding Source: Medline
- NIGMS NIH HHS [R01 GM59290] Funding Source: Medline
- EAPO CDC HHS [EPS-0346411] Funding Source: Medline
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As is the case with mammals in general, primate genomes are inundated with repetitive sequence. Although much of this repetitive content consists of molecular fossils inherited from early mammalian ancestors, a significant portion of this material comprises active mobile element lineages. Despite indications that these elements played a major role in shaping the architecture of the genome, there remain many unanswered questions surrounding the nature of the host-element relationship. Here we review advances in our understanding of the host-mobile element dynamic and its overall impact on primate evolution.
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