4.3 Article Proceedings Paper

A design for life: Prokaryotic metal-binding MerR family regulators

Journal

BIOMETALS
Volume 18, Issue 4, Pages 429-436

Publisher

SPRINGER
DOI: 10.1007/s10534-005-3717-7

Keywords

CueR; cysteine coordination; MerR; MerR regulators; PbrR; ZntR

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The MerR family of metal-binding, metal-responsive proteins is unique in that they activate transcription from unusual promoters and coordinate metals through cysteine (and in the case of ZntR, histidine) residues. They have conserved primary structures yet can effectively discriminate metals in vivo.

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