Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 6, Issue 8, Pages 610-621Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm1701
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Funding
- NIGMS NIH HHS [R01 GM059135] Funding Source: Medline
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Ubiquitin-binding domains (UBDs) are a collection of modular protein domains that non-covalently bind to ubiquitin. These recently discovered motifs interpret and transmit information conferred by protein ubiquitylation to control various cellular events. Detailed molecular structures are known for a number of UBDs, but to understand their mechanism of action, we also need to know how binding specificity is determined, how ubiquitin binding is regulated, and the function of UBDs in the context of full-length proteins. Such knowledge will be key to our understanding of how ubiquitin regulates cellular proteins and processes.
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