Journal
NATURE NEUROSCIENCE
Volume 8, Issue 8, Pages 1013-1021Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn1505
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Funding
- NEI NIH HHS [P30 EY012576, EY11369, EY015387, R01 EY011369, T32 EY015387, R01 EY011369-11, R01 EY014689, EY14689-01, EY12576] Funding Source: Medline
- NINDS NIH HHS [R01 NS039094, NS39094] Funding Source: Medline
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Axon guidance cues contributing to the development of eye-specific visual projections to the lateral geniculate nucleus (LGN) have not previously been identified. Here we show that gradients of ephrin-As and their receptors (EphAs) direct retinal ganglion cell (RGC) axons from the two eyes into their stereotyped pattern of layers in the LGN. Overexpression of EphAs in ferret RGCs using in vivo electroporation induced axons from both eyes to misproject within the LGN. The effects of EphA overexpression were competition-dependent and restricted to the early postnatal period. These findings represent the first demonstration of eye-specific pathfinding mediated by axon guidance cues and, taken with other reports, indicate that ephrin-As can mediate several mapping functions within individual target structures.
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