Journal
EXPERIMENTAL EYE RESEARCH
Volume 81, Issue 2, Pages 123-137Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exer.2005.03.006
Keywords
plasticity; computational molecular phenotyping; retina; remodeling; amacrine cell; photoreceptor; ganglion cell; bipolar cell; horizontal cell; retinitis pigmentosa; RCS; rd1; rd2; or(J); pcd; nr(J); GHL; rho Delta CTA; TG9N; rdcl; P23H; S334ter; or(J)+P27Kip1(-/-); rho(-/-); elovl4(-/-); hrhoG; hrhoG(H); hrhoG+rd1; light damage
Categories
Funding
- NEI NIH HHS [EY 002576, EY 015128] Funding Source: Medline
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Retinal degenerations, regardless of the initiating event or gene defect, often result in a loss of photoreceptors. This formal deafferentation of the neural retina eliminates the intrinsic glutamatergic drive of the sensory retina and, perhaps more importantly, removes coordinated Ca++-coupled signaling to the neural retina. As in other central nervous system degenerations, deafferentation activates remodeling. Neuronal remodeling is the common fate of all photoreceptor degenerations. (c) 2005 Elsevier Ltd. All rights reserved.
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