Journal
JOURNAL OF PHARMACOLOGICAL SCIENCES
Volume 98, Issue 4, Pages 463-466Publisher
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jphs.SC0050130
Keywords
nafamostat mesilate; interleukin-18; interleukin-12
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Little has been reported on the drugs inducing production of monocyte-derived cytokines like interleukin (IL)-18 and IL-12. We found that nafamostat mesilate elicits IL-12, IL-18, tumor necrosis factor-alpha and interferon-gamma production, and the expression of intercellular adhesion molecules-1, B7.1, B7.2, CD40, and CD40 ligand in human peripheral blood mononuclear cells. The cytokine production and adhesion molecule expression were abolished by anti-IL-12 and IL-18 antibodies. Therefore, IL-18 and IL-12 may play roles in the significant and immediate effects of nafamostat mesilate.
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