Journal
NATURE NEUROSCIENCE
Volume 8, Issue 8, Pages 985-987Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn1432
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Funding
- NINDS NIH HHS [NS36715, R01 NS036715] Funding Source: Medline
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The C-terminal PDZ ligand of the AMPA receptor GluR1 subunit may be important for expression of CA1 hippocampal long-term potentiation. To test this directly in vivo, we generated a knock-in mouse lacking the last seven residues of GluR1, comprising the PDZ ligand. This deletion did not affect basal GluR1 synaptic localization, basal synaptic transmission, long-term potentiation or long-term depression, indicating that the ligand is not required for CA1 hippocampal synaptic plasticity.
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