Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 40, Issue 8, Pages 816-819Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2005.02.009
Keywords
quinazolines; solvent free; antibacterial activity; microwave irradiation
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A novel. ecofriendly, one pot solvent free method for the synthesis of 4-aryl-7.7-dimethyl- 1.2,3,4,5,6,7,8-octahydroquinazoline-2-one/thiotie-5-one derivatives is described which devoids the use of any organic solvents and auxiliaries. All the synthesized Compounds were screened for their in vitro antibacterial activity against standard strains of Staphylococcus aureus. Escherichia coli and Pseudomonas aeruginosa. (c) 2005 Elsevier SAS. All rights reserved.
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