Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 115, Issue 8, Pages 2047-2058Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI25495
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- Wellcome Trust Funding Source: Medline
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ATP-sensitive potassium (K-ATP) channels, so named because they are inhibited by intracellular ATP, play key physiological roles in many tissues. In pancreatic beta cells, these channels regulate glucose-dependent insulin secretion and serve as the target for sulfonylurea drugs used to treat type 2 diabetes. This review focuses on insulin secretory disorders, such as congenital hyperinsulinemia and neonatal diabetes, that result from mutations in K-ATP channel genes. It also considers the extent to which defective regulation of K-ATP channel activity contributes to the etiology of type 2 diabetes.
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