Journal
JOURNAL OF ANTIBIOTICS
Volume 58, Issue 8, Pages 530-534Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ja.2005.73
Keywords
resistomycin; 1-hydroxy-1-norresistomycin; marine streptomycetes; natural product; structure elucidation
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Cultivation of the marine-derived streptomycete isolate B8005 delivered three known antibiotics, resistomycin (1), resistoflavin (3a) and tetracenomycin (4), and a further member of the rare resistomycin class, the weakly antibiotically active 1-hydroxy-1-norresistomycin (2). From a related marine strain B4842, 1 and resistoflavin methyl ether (3b) have been isolated. The formation of 2 is of interest from a biosynthetic point of view.
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