4.6 Article

Isolation and Characterization of Enterocin W, a Novel Two-Peptide Lantibiotic Produced by Enterococcus faecalis NKR-4-1

Journal

APPLIED AND ENVIRONMENTAL MICROBIOLOGY
Volume 78, Issue 3, Pages 900-903

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.06497-11

Keywords

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Funding

  1. Yamaguchi University
  2. Kasetsart University
  3. Japan Society for the Promotion of Science (JSPS)
  4. National Research Council of Thailand (NRCT)
  5. Kyushu University
  6. Kato Memorial Bioscience Foundation
  7. Grants-in-Aid for Scientific Research [22780069] Funding Source: KAKEN

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Enterococcus faecalis NKR-4-1 isolated from pla-ra produces a novel two-peptide lantibiotic, termed enterocin W, comprising W alpha and W beta. The structure of enterocin W exhibited similarity with that of plantaricin W. The two peptides acted synergistically, and their order of binding to the cell membrane was important for their inhibitory activity.

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