Journal
INTERVIROLOGY
Volume 58, Issue 5, Pages 278-282Publisher
KARGER
DOI: 10.1159/000441473
Keywords
Multiple sclerosis; JC virus; Triggering agent
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Funding
- Italian Ministry of Education, University and Research (PRIN)
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Multiple sclerosis (MS) is an autoimmune, demyelinating disorder of unknown etiology, in which viruses have been suggested as etiological/triggering agents. The attention to the association between viruses and MS has been rekindled by the development of progressive multifocal leukoencephalopathy in natalizumab-treated MS patients. Here we report the case of a woman with JC virus (JCV) replication in the cerebrospinal fluid, blood and urine collected at the first symptoms of MS and during several follow-up visits. This observation shows that JCV can be associated with MS without a relation with natalizumab treatment, although the triggering role of JCV in some cases of MS will require further studies. (C) 2015 S. Karger AG, Basel
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