Journal
NATURE IMMUNOLOGY
Volume 6, Issue 8, Pages 793-799Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni1227
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Funding
- NIAID NIH HHS [R01 AI041576, F32 AI053970, AI41576, AI053970, R01 AI041576-10] Funding Source: Medline
- NIDDK NIH HHS [R01 DK045260-15, R01 DK045260, DK45260] Funding Source: Medline
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Memory T cells can be divided into central memory T cell (TCM cell) and effector memory T cell (TEM cell) subsets based on homing characteristics and effector functions. Whether TEM and TCM cells represent interconnected or distinct lineages is unclear, although the present paradigm suggests that TEM and TCM cells follow a linear differentiation pathway from naive T cells to effector T cells to TEM cells to TCM cells. We show here that naive T cell precursor frequency profoundly influenced the pathway along which CD8(+) memory T cells developed. At low precursor frequency, those TEM cells generated represented a stable cell lineage that failed to further differentiate into TCM cells. These findings do not adhere to the present dogma regarding memory T cell generation and provide a means for identifying factors controlling memory T cell lineage commitment.
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