Journal
ATHEROSCLEROSIS
Volume 181, Issue 2, Pages 353-362Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2005.01.019
Keywords
atherosclerosis; omega-3 fatty acids; Alaska native; diet
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Essential polyunsaturated fatty acids (PUFA) of the omega-3 family are believed to protect against cardiovascular disease. A rich source of omega-3 PUFA is found in fish and marine mammals (seat, walrus, whale), which are a large part of the traditional diet of Alaska Natives (Eskimo, American Indians, Aleuts), a group that has been reported to have a lower mortality rate from cardiovascular disease than non-Natives. An autopsy study using standardized methods to evaluate the extent of atherosclerosis and its risk factors, and analyses of stored triglyceride fatty acids was conducted in a sample of Alaska Native subjects and non-Native subjects living in Alaska. Findings indicate that Alaska Natives had less advanced atherosclerosis in coronary arteries, along with higher proportions of omega-3 and lower proportions of omega-6 PUFA in adipose tissue. than did non-Natives. We conclude that high dietary intake of omega-3 PUFA may account for the lower extent of coronary artery atherosclerosis. contributing to the reported lower heart disease mortality among Alaska Natives. Published by Elsevier Ireland Ltd.
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