Journal
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
Volume 77, Issue 14, Pages 5040-5043Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.02880-10
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Funding
- European Union [LSHP-CT-2005-018923]
- St. Bartholomew's and the Royal London Charitable Foundation [RAB 03/PJ/0]
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We constructed recombinant strains of Mycobacterium tuberculosis in which expression of specific genes was downregulated to identify vulnerable drug targets. Growth phenotypes in macrophages and culture were used to rank targets: the dprE1, clpP1, and fadD32 operons were the best targets and glnA1, glnE, pknL, regX3, and senX3 were poor targets.
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