Journal
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
Volume 20, Issue 4, Pages 436-449Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/cbr.2005.20.436
Keywords
Y-90; Re-188; Ho-166; Pm-149; Lu-177; Cu-64; beta-emitter dosimetry; Medical Internal Radiation Dose (MIRD) estimates; mouse model; molecular targeted radionuclide therapy; radioimmunotherapy; MCNP; PEREGRINE; small-scale dosimetry; S-factors
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Several short-lived, high-energy beta emitters are being proposed as the radionuclide components for molecular-targeted potential cancer therapeutic agents. The laboratory mice used to determine the efficacy of these new agents have organs that are relatively small compared to the ranges of these high-energy particles. The dosimetry model developed by Hui et al. was extended to provide realistic beta-dose estimates for organs in mice that received therapeutic radiopharmaceuticals containing Y-90, Re-188, Ho-166, Pm-149, Cu-64, and Lu-177. Major organs in this model included the liver, spleen, kidneys, lungs, heart, stomach, small and large bowel, thyroid, pancreas, bone, marrow, carcass, and a 0.025-g tumor. The study as reported in this paper verifies their results for Y-90 and extends them by using their organ geometry factors combined with newly calculated organ self-absorbed fractions from PEREGRINE and MCNP. PEREGRINE and MCNP agree to within 8% for the worst-case organ with average differences (averaged over all organs) decreasing from 5% for Y-90 to 1% for Lu-177. When used with typical biodistribution data, the three different models predict doses that are in agreement to within 5% for the worst-case organ. The beta-absorbed fractions and cross-organ-deposited energy provided in this paper can be used by researchers to predict mouse-organ doses and should contribute to an improved understanding of the relationship between dose and radiation toxicity in mouse models where use of these isotopes is favorable.
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