Journal
SEMINARS IN IMMUNOLOGY
Volume 17, Issue 4, Pages 253-261Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2005.05.008
Keywords
virus; toll-like receptor; interferon; interferon-producing cell; plasmacytoid dendritic cell
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Plasmacytoid dendritic cells (pDC) have emerged as a principal subset of dendritic cells in both human and mouse. PDC morphology, surface markers, their migration in vivo and the ability to rapidly produce large amounts of type 1 interferons (IFN-alpha/beta) in response to toll like receptor (TLR) triggering sets them apart from other dendritic cell subsets. This review highlights the features that make pDC uniquely able to sense and respond to viral infection. (c) 2005 Elsevier Ltd. All rights reserved.
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