Journal
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
Volume 76, Issue 19, Pages 6449-6454Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.02987-09
Keywords
-
Categories
Funding
- Spanish Ministerio de Educacion y Ciencia/FEDER [AGL2005-02542]
- Consolider-Ingenio [CSD2007-0063]
- CICYT
Ask authors/readers for more resources
Linalool production was evaluated in different Saccharomyces cerevisiae strains expressing the Clarkia breweri linalool synthase gene (LIS). The wine strain T-73 was shown to produce higher levels of linalool than conventional laboratory strains (i.e., almost three times the amount). The performance of this strain was further enhanced by manipulating the endogenous mevalonate (MVA) pathway: deregulated overexpression of the rate-limiting 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) doubled linalool production. In a haploid laboratory strain, engineering of this key step also improved linalool yield.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available