Journal
PARKINSONISM & RELATED DISORDERS
Volume 11, Issue 5, Pages 323-325Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.parkreldis.2005.02.009
Keywords
Parkinson's disease; hypergraphia; increased writing; dopamine; quetiapine
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We report a 32-year-old male patient with early-onset Parkinson's disease who exhibited abnormally increased writing activity. The patient displayed a disabling and pronounced increased writing activity, filling up to 10 pages or more per day in a notebook, and spending more than 12 h writing. In general, there was not much meaning in most of the writing, though there was a particular preference in tabulating the names of various sport and TV personalities. The writing activity gradually diminished following treatment with quetiapine hydrochloride, an anti-psychotic agent, at 25 mg/day. Although the pathophysiological mechanism underlying the increased writing is unclear, we believe it should be regarded as a form of punding or stereotyped behavior that has been suggested to be associated with dopaminergic therapy in Parkinson's disease. (C) 2005 Elsevier Ltd. All rights reserved.
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