Journal
CURRENT CANCER DRUG TARGETS
Volume 5, Issue 5, Pages 357-363Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568009054629681
Keywords
4-1BB; CD8(+) T cells; cancer; signaling pathways
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Techniques for modulating immune cells for cancer therapy have been widely studied. One key approach that is being clinically tested is developing tumor-destructive cell-mediated immune responses by regulating co-stimulatory molecules. 4-IBB (CD137), a member of the TNF receptor family, is expressed following activation of T and NK cells. Recently, it has been reported that DCs also express 4-IBB. Crosslinking of 4-IBB provides a potent co-stimulatory signal for lymphocytes via signal transduction pathways that modulate a number of cellular responses. One remarkable response is stimulation of anti-tumor activity in vivo and in vitro. We here review the potential role of 4-IBB in cancer immunotherapy focusing on the cellular and molecular mechanisms involved.
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