4.6 Article

Selection of Bifidobacteria Based on Adhesion and Anti-Inflammatory Capacity In Vitro for Amelioration of Murine Colitis

Journal

APPLIED AND ENVIRONMENTAL MICROBIOLOGY
Volume 76, Issue 9, Pages 3048-3051

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.03127-09

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Funding

  1. German Academic Exchange Service/Federal Ministry of Education and Research [D/09/04778]
  2. DFG [Ni575/6-2, Ni575/7-1]
  3. Carl Zeiss Foundation

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Adhesion and anti-inflammatory properties of eight strains of bifidobacteria were tested using the intestinal epithelial cell lines Caco-2, T84, and HT29. Two strains were selected for further assessment of their anti-inflammatory capacity in two murine models of colitis. In vivo results confirmed the high anti-inflammatory capacity of a Bifidobacterium bifidum strain.

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