Journal
AMERICAN JOURNAL OF HUMAN GENETICS
Volume 77, Issue 2, Pages 318-326Publisher
CELL PRESS
DOI: 10.1086/432647
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Funding
- NHGRI NIH HHS [N01HG65403] Funding Source: Medline
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Between 40% and 80% of the variation in human intelligence ( IQ) is attributable to genetic factors. Except for many rare mutations resulting in severe cognitive dysfunction, attempts to identify these factors have not been successful. We report a genomewide linkage scan involving 634 sibling pairs designed to identify chromosomal regions that explain variation in IQ. Model-free multipoint linkage analysis revealed evidence of a significant quantitative-trait locus for performance IQ at 2q24.1-31.1 (LOD score 4.42), which overlaps the 2q21-33 region that has repeatedly shown linkage to autism. A second region revealed suggestive linkage for both full-scale and verbal IQs on 6p25.3-22.3 ( LOD score 3.20 for full-scale IQ and 2.33 for verbal IQ), overlapping marginally with the 6p22.3-21.31 region implicated in reading disability and dyslexia.
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