Journal
CLINICAL MICROBIOLOGY AND INFECTION
Volume 11, Issue 8, Pages 602-610Publisher
ELSEVIER SCI LTD
DOI: 10.1111/j.1469-0691.2005.01207.x
Keywords
CagA; cytotoxin; Helicobacter pylori; pathogenicity island; review; vacA
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Numerous Helicobacter pylori virulence factors, including various enzymes (urease, catalase, lipase, phospholipase and proteases), vacuolating cytotoxin (a product of expression of the vacA gene), and the immunogenic protein CagA, encoded by the cagA gene localised in the H. pylori pathogenicity island, are involved in the pathomechanism of infection caused by these organisms. This review presents the current state of knowledge concerning the molecular mechanisms and epidemiology of H. pylori infection, based on the published literature and recent unpublished observations.
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