Journal
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
Volume 28, Issue 2, Pages 346-348Publisher
OXFORD UNIV PRESS INC
DOI: 10.1016/j.ejcts.2005.05.004
Keywords
Noonan's syndrome; giant sinus of valsalva aneurysms; aortic regurgitation
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Noonan's syndrome is one of the commonest hereditary syndromes with cardiac involvement. We report a rare presentation of this syndrome, associated with giant aneurysms of the left and non-coronary sinuses of Vatsalva, resulting in symptomatic aortic valve regurgitation. The patient's clinical investigations and operative management are presented. Histological examination of aortic tissues offers insight into the pathogenesis of these complications. (c) 2005 Elsevier B.V. All rights reserved.
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