Heterologous Expression of the Oxytetracycline Biosynthetic Pathway in Myxococcus xanthus

New natural products for drug discovery may be accessed by heterologous expression of bacterial biosynthetic pathways in metagenomic DNA libraries. However, a universal host is needed for this experiment. Herein, we show that Myxococcus xanthus is a potential universal host for heterologous expression of polyketide biosynthetic gene clusters.