Journal
JOURNAL OF IMMUNOLOGY
Volume 175, Issue 3, Pages 1373-1381Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.175.3.1373
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Funding
- NCI NIH HHS [R01 CA83070, P01 CA59350, P01 CA23766, R21 CA97714, R21 CA105718] Funding Source: Medline
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Dendritic cells (DCs) are specialized, bone marrow-derived Leukocytes that are critical to the development of immunity. Investigators have emphasized the role of DCs in initiating adaptive or acquired MHC-restricted, Ag-specific T cell responses. More recent evidence supports important roles for DCs in the onset of innate immunity and peripheral tolerance. Progress in the generation of DCs from defined hemopoietic precursors in vitro has revealed the heterogeneity of these APCs and their attendant divisions of labor. This review will address these developments in an attempt to integrate the activities of different DCs in coordinating innate and adaptive immunity.
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