4.5 Article

Glycosidase inhibition by 1-glycosyl-4-phenyl triazoles

Journal

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 15, Issue 15, Pages 3596-3599

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2005.05.081

Keywords

glycosidase; triazole; click; cycloaddition

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1-Glycosyl-4-phenyl triazoles have been prepared via a copper-mediated [3 + 2] cycloaddition of glycosyl azides with phenylacetylene. These triazoles have been evaluated for their ability to inhibit the enzymatic activity of glycosidases. (c) 2005 Elsevier Ltd. All rights reserved.

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