Journal
FEBS LETTERS
Volume 579, Issue 19, Pages 4119-4124Publisher
WILEY
DOI: 10.1016/j.febslet.2005.06.040
Keywords
red blood cells; nitric oxide; S-nitrosothiols; S-nitrosocysteine; transport; platelet aggregation
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The transport of various S-nitrosothiols, NO and NO donors in human red blood cells (RBC) and the formation of erythrocytic S-nitrosoglutathione were investigated. Of the NO species tested only S-nitrosocysteine was found to form S-nitrosoglutathione in the RBC cytosol. L-Serine, L-cysteine and L-lysine inhibited formation of S-nitrosoglutathione. Incubation of RBC pre-incubated with S-[N-15]nitroso-L-cysteine with native plasma or platelet-rich plasma led to formation of S-[N-15]nitrosoalbumin and inhibited platelet aggregation, respectively. The specific transporter system of S-nitroso-L-cysteine in the RBC membrane may have implications for formation of S-nitrosoalbumin and S-nitrosohemoglobin and for transport of NO bioactivity within the vasculature. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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