Journal
NEUROBIOLOGY OF AGING
Volume 26, Issue 8, Pages 1215-1227Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2004.09.017
Keywords
aging; white matter; prefrontal; motor; corticospinal; internal capsule; myelin
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Funding
- NCRR NIH HHS [RR14075, P41:RR14075] Funding Source: Medline
- NIA NIH HHS [5:P50:AG05134, AG05886, AG14432] Funding Source: Medline
- NINDS NIH HHS [NS39581] Funding Source: Medline
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Cerebral white matter (WM) undergoes various degenerative changes with normal aging, including decreases in myelin density and alterations in myelin structure. We acquired whole-head, high-resolution diffusion tensor images (DTI) in 38 participants across the adult age span. Maps of fractional anisotropy (FA), a measure of WM microstructure, were calculated for each participant to determine whether particular fiber systems of the brain are preferentially vulnerable to WM degeneration. Regional FA measures were estimated from nine regions of interest in each hemisphere and from the genu and splenium of the corpus callosurn (CC). The results showed significant age-related decline in FA in frontal WM, the posterior limb of the internal capsule (PLIC), and the genu of the CC. In contrast, temporal and posterior WM was relatively preserved. These findings suggest that WM alterations are variable throughout the brain and that particular fiber populations within prefrontal region and PLIC are most vulnerable to age-related degeneration. (c) 2004 Published by Elsevier Inc.
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