Journal
CHEMBIOCHEM
Volume 6, Issue 8, Pages 1368-1374Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.200500035
Keywords
cosmic-dust analogues; nucleic acids; nucleobases; oligonucleotides; pyrimidines
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We show the unprecedented one-pot synthesis of a large suite of pyrimidines (including cytosine and uracil) and purines from formomide in the presence of cosmic-dust analogues (CDAs) of olivines. Since the major problem in the origin of informational macromolecules is the instability of their precursors, we also investigate the stabilizing effect of CDAs on the intrinsic instability of oligonucleotides in formamide.
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